Research Paper Volume 12, Issue 12 pp 11568—11578

Integrative analysis of miRNAs-mRNAs reveals that miR-182 up-regulation contributes to proliferation and invasion of nasopharyngeal carcinoma by targeting PTEN

Figure 4. MiR-182 promoted proliferation and invasion of NPC cells via targeting PTEN. (A) The complementary binding sites of miR-182 and 3′UTR of PTEN. (B) The dual-luciferase reporter assays were performed to verify the target prediction. (C) MiR-182 mimics/inhibitors significantly reduced/increased PTEN expression. (D) PTEN expression was significantly increased after transfection. (E) Overexpression of PTEN abrogates the promotion effect of miR-182 mimics on NPC invasion. P < 0.05.