Research Paper Volume 12, Issue 12 pp 11314—11324

Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age

Figure 1. Aortic SIRT-1 mRNA gene expression (A) in wild-type (WT) and SIRT-1 transgenic overexpressing (SIRTTG) mice (N=4-8/group) normalized to Young WT. Scatter plot (B) of aortic pulse wave velocity (PWV) with advancing age in WT and SIRTTG mice. Separate regression lines are given for WT and SIRTTG mice (dotted lines define 95% confidence intervals). Aortic PWV measured at 3 mo increments in WT (C) and SIRTTG (D) mice (N=7-24/group). *P<0.05 vs. WT in same age group. P<0.05 vs. Young. a, b, c, d, e, f P<0.05 vs. 3, 6, 9, 12, 15, 18, 21 mo, respectively. Data are mean±SEM.