Research Paper Volume 12, Issue 12 pp 11314—11324

Figure 1. Aortic SIRT-1 mRNA gene expression (A) in wild-type (WT) and SIRT-1 transgenic overexpressing (SIRT^TG) mice (N=4-8/group) normalized to Young WT. Scatter plot (B) of aortic pulse wave velocity (PWV) with advancing age in WT and SIRT^TG mice. Separate regression lines are given for WT and SIRT^TG mice (dotted lines define 95% confidence intervals). Aortic PWV measured at 3 mo increments in WT (C) and SIRT^TG (D) mice (N=7-24/group). *P<0.05 vs. WT in same age group. ^†P<0.05 vs. Young. a, b, c, d, e, f P<0.05 vs. 3, 6, 9, 12, 15, 18, 21 mo, respectively. Data are mean±SEM.