Research Paper Volume 12, Issue 12 pp 11314—11324

Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age

Figure 2. Thoracic aorta lumen diameter (A), medial cross-sectional area (B [CSA]), and media-to-lumen ratio (C) in young, middle-age, and old wild-type (WT) and SIRT-1 transgenic overexpressing (SIRTTG) mice. *P<0.05 vs. WT in same age group. P<0.05 vs. Young. P<0.05 vs. Middle-Age. Data are individual values and means.