Research Paper Volume 12, Issue 12 pp 11314—11324

Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age

Figure 3. Total thoracic aortic elastin (A), collagen (B), and advanced glycation end products (C [AGEs]) content in young, middle-age, and old wild-type (WT) and SIRT-1 transgenic overexpressing (SIRTTG) mice. Figures are accompanied by representative images of elastin, collagen, and AGEs staining. Black scale bars are equal to 200 μm. *P<0.05 vs. WT. P<0.05 vs. Young. P<0.05 vs. Middle-Age. Data are individual values and means normalized to Young WT.