Research Paper Volume 12, Issue 12 pp 11623—11635

Silencing of hsa_circ_0101145 reverses the epithelial-mesenchymal transition in hepatocellular carcinoma via regulation of the miR-548c-3p/LAMC2 axis

Figure 4. Downregulation of hsa_circ_0101145 suppressed tumor metastasis in vivo and in vitro. (A and B) Transwell cell migration assays in HepG2 and Huh-7 cells. Data are means ± SD. ***P < 0.001 vs. NC. (C and D) Wound-healing assays showing the effect of hsa_circ_0101145 on the closure of scratch wounds. Data are presented as the mean ± SD. ***P < 0.001 vs. NC. (E) Live imaging shows the effects of hsa_circ_0101145 on the metastasis of HepG2 cells 30 days after intravenous tail injection.