Deoxyelephantopin induces apoptosis via oxidative stress and enhances gemcitabine sensitivity <i>in vitro</i> and <i>in vivo</i> through targeting the NF-κB signaling pathway in pancreatic cancer

Daolin Ji; Xiangyu Zhong; Peng Huang; Pengcheng Kang; Kaiming Leng; Wangyang Zheng; Zhidong Wang; Yi Xu; Yunfu Cui

doi:doi:10.18632/aging.103327

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Research Paper Volume 12, Issue 11 pp 11116—11138

Deoxyelephantopin induces apoptosis via oxidative stress and enhances gemcitabine sensitivity in vitro and in vivo through targeting the NF-κB signaling pathway in pancreatic cancer

Figure 4. Effect of DET on apoptosis-related proteins. (A, B) DET activated apoptosis-related proteins in BxPC-3 and CFPAC-1 cells in a concentration dependent manner. Quantitative statistics of immunoblotting analysis for Bax levels (C, D), Bcl-2 levels (E, F), cytochrome c levels (G, H), cleaved caspase-9 levels (I, J), cleaved caspase-3 levels (K, L), *P < 0.05, **P < 0.01 versus CTL. CTL, control.