Research Paper Volume 12, Issue 11 pp 11139—11151

Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases

Figure 3. Melatonin ameliorated PrP106-126-induced mitochondrial fragmentation in N2a cells. Mitochondrial morphology was detected by confocal microscopy (A) and mitochondrial length (B), area (C) and aspect ratio (AR) (D) were analyzed by the ImageJ software. *P < 0.05, ***P < 0.001. All experiments were repeated at least three times.