Research Paper Volume 12, Issue 11 pp 11139—11151

Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases

Figure 5. Melatonin completely prevented the effect of PrP106-126 on the protein expression of DRP1 and OPA1. Mitochondrial fusion proteins (MFN1, MFN2, and OPA1) (A, B) and mitochondrial fission proteins (DRP1 and FIS1) (C, D) in N2a cells and DRP1 in mitochondria (E, F) by Western blotting. *P < 0.05, **P < 0.01 All experiments were repeated at least three times.