Research Paper Volume 12, Issue 12 pp 11636—11652

PLK1 Inhibition alleviates transplant-associated obliterative bronchiolitis by suppressing myofibroblast differentiation

Figure 6. PLK1 inhibition suppresses TGFβ-mediated differentiation of myofibroblasts via the MAPK-ERK pathway. (AD) The mouse myofibroblast TGF-β1 differentiation model was employed, with the addition of BI6727 to inhibit PLK1. Representative immunoblots for MEK, ERK, phosphorylated SMAD3, and GAPDH at various timepoints are shown. The results were quantified by densitometry, as represented in the bar diagrams. * P≤0.05.