Research Paper Volume 12, Issue 12 pp 11685—11697

Long noncoding RNA KCNQ1OT1 promotes colorectal carcinogenesis by enhancing aerobic glycolysis via hexokinase-2

Figure 1. High KCNQ1OT1 levels correlate with worse prognosis in colorectal cancer patients. (A) QRT-PCR analysis shows that KCNQ1OT1 levels in colorectal tissues compared to adjacent normal colorectal tissue samples from 79 colorectal cancer patients. (B) QRT-PCR analysis shows that KCNQ1OT1 levels are 4-fold higher in colorectal tissues compared to adjacent normal colorectal tissue samples from 79 colorectal cancer patients. (C) Receiver Operating Characteristic (ROC) curve analysis shows clinical sensitivity and specificity of KCNQ1OT1 expression in 79 colorectal cancer patients. (D) Kaplan–Meier survival curve analysis shows overall survival (OS) of high- and low- KCNQ1OT1expressing colorectal cancer patients. (E) Kaplan–Meier survival curve analysis shows disease-free survival (DFS) of high- and low-KCNQ1OT1expressing colorectal cancer patients.