Research Paper Volume 12, Issue 12 pp 11685—11697

Long noncoding RNA KCNQ1OT1 promotes colorectal carcinogenesis by enhancing aerobic glycolysis via hexokinase-2

Figure 6. HK2 protein levels correlate with prognosis and KCNQ1OT1 expression in CRC patients. (A) Representative images show immunohistochemical staining of HK2 protein in 79 pairs of colorectal cancer and adjacent normal colorectal tissues using anti-HK2 antibodies. (B) QRT-PCR analysis shows HK2 mRNA levels in 79 pairs of colorectal cancer and adjacent normal colorectal tissues. (C) Kaplan–Meier survival curve analysis shows overall survival (OS) of colorectal cancer patients with low and high levels of HK2 mRNA. (D, E) Correlation analysis shows the relationship between HK2 expression (based on IHC analysis) and lncRNA KCNQ1OT1 levels (qRT-PCR) in 79 colorectal cancer patients. Note: ***p < 0.001.