First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds

Béla Ózsvári; Federica Sotgia; Michael P. Lisanti

doi:doi:10.18632/aging.103336

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Research Paper Volume 12, Issue 11 pp 10162—10179

First-in-class candidate therapeutics that target mitochondria and effectively prevent cancer cell metastasis: mitoriboscins and TPP compounds

Figure 10. Effects of Dodecyl-TPP on cancer metastasis. Dodecyl-TPP was tested using low micro-molar concentrations (6.25- and 25-μM). Note that Dodecyl-TPP significantly inhibited metastasis (by 25% to 65%). Averages are shown + SEM. *p<0.05; ***p<0.001. Importantly, little or no toxicity was observed for Dodecyl-TPP at 6.25- and 25-μM (Table 3). The structure of Dodecyl-TPP (d-TPP) is also shown.