Research Paper Volume 12, Issue 12 pp 11717—11731

Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling

Figure 3. Resveratrol inhibits HCC cell motility. (A) In a wound-healing assay, HepG2 and Hep3B cells were treated with different concentrations of resveratrol for 24 h. The wound area was measured at indicated times. Representative images are shown. (B, C) Cell tran-swell assays (with or without a Matrigel coating). HepG2 and Hep3B cells were seeded in the upper chamber and cultured in serum-free medium containing resveratrol. After 24 h, the membrane was stained with crystal violet solution and photographed. The results of quantification analysis are presented. All values represent the mean ± SD. **P < 0.01; *P < 0.05.