Research Paper Volume 12, Issue 12 pp 11717—11731

Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling

Figure 6. Model for resveratrol regulating MARCH1 expression. Resveratrol decreased MARCH1 expression, increased PTEN expression, and decreased AKT phosphorylation, STAT3 phosphorylation. On the whole, resveratrol inhibits the malignant progression of HCC via MARCH1-induced regulation of the PTEN/AKT/STAT3 signaling pathway. The expression of downstream effectors VEGF and Bcl2 decreased.