Figure 1. Effect of aging on the modulation of microRNA expression. (A, B) Venn diagrams showing the number of miRNAs that are downregulated (A) or upregulated (B) in Mouse Aortic Endothelial Cells (MAECs) and ischemic muscles from old vs. young mice, as assessed by next-generation sequencing (pool of 3-4 mice/group). miRNAs modulated both in MAECs and ischemic muscles are listed. (C) List of miRNAs modulated by at least 15% in old animals both in MAECs and ischemic muscles. Validated targets and potential pathways involved are shown for each miRNA.