Research Paper Volume 12, Issue 12 pp 11768—11780

L-3-n-butylphthalide attenuates inflammation response and brain edema in rat intracerebral hemorrhage model

Figure 4. NBP attenuated inflammation and brain edema in intracerebral hemorrhage. NBP treatment substantially inhibit the inflammation, reduced ICH-induced brain edema, and then protected the BBB from disruption. BBB: blood-brain barrier; CNS: central nervous system; MMP-9: matrix metalloproteinase-9; NBP: butylphthalide; ROS:reactive oxygen species; TNF-α: tumor necrosis factor-alpha.