Research Paper Volume 12, Issue 12 pp 11781—11793

Astrocyte-derived VEGF increases cerebral microvascular permeability under high salt conditions

Figure 7. Blocking VEGF attenuates disruption of tight junctions induced by HSD. (A) Representative images showing double immunofluorescence staining of ZO-1 in green and DAPI in the brain specimens of rats. (B, C) Expression of Occludin, Claudin-5 and ZO-1 determined by western blotting; n=5, *P<0.05, **P<0.01, compared with NSD. At least three separate experiments were conducted; means ± SD.