Research Paper Volume 12, Issue 12 pp 11794—11811

GALNT6 promotes breast cancer metastasis by increasing mucin-type O-glycosylation of α2M

Figure 4. Effect of GALNT6 on MDA-MB-231 and MDA-MB-468 cell migration and invasion. (A) GALNT6 expression was detected by western blot in MDA-MB-231 and MDA-MB-468 cells, respectively (left). The efficiency of GALNT6 knock-down in MDA-MB-231 cells (middle) and overexpression in MDA-MB-468 cells (right). β-actin was used as internal control. (BE) The effect of GALNT6-knockdown or -overexpression on migratory and invasive abilities of MDA-MB-231 and MDA-MB-468 cells.