Research Paper Volume 12, Issue 12 pp 12032—12050

CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses

Figure 3. Aged CD70+ T cells show a phenotype of over activation. Flow cytometry analysis of percentage of HLA-DR+ CD38hi cells (AB), and expression of CD28 (CD) and CD27 (EF) on CD70- vs. CD70+ CD4+ and CD8+ T cells from elderly individuals (61-80 years, n = 17). Representative flow data or histograms (left) and plots (right) display the expression of the above receptors on CD70- vs. CD70+ cells (gated with CD4+ or CD8+ T cells). The p-values were obtained by paired t-test (HLA-DR+CD38hi [CD4+ T cells], CD28, CD27) or Wilcoxon matched-pairs signed rank test (HLA-DR+CD38hi [CD8+ T cells]). ***p < 0.001.