Research Paper Volume 12, Issue 12 pp 12074—12085

Agonism of GPR120 prevented IL-1β-induced reduction of extracellular matrix through SOX-9

Figure 3. Treatment with GW9508 reduced IL-1β-induced generation of inflammatory cytokines in ATDC5 chondrocytes. Cells were treated with IL-1β (10 ng/ml) with or without GW9508 (50 μM) for 24 h. (A). mRNA of IL-6 and IL-8; (B). Protein secretions of IL-6 and IL-8 (^^^, P<0.0001 vs. control group; ***, P<0.0001 vs. IL-1β treatment group, n=4-5).