Research Paper Volume 12, Issue 12 pp 12074—12085

Agonism of GPR120 prevented IL-1β-induced reduction of extracellular matrix through SOX-9

Figure 5. Treatment with GW9508 restored IL-1β-induced reduction of SOX-9 in ATDC5 chondrocytes. Cells were treated with IL-1β (10 ng/ml) with or without GW9508 (50 μM) for 24 h. (A). mRNA of SOX-9; (B). Protein of SOX-9 (^^^, ***, P<0.0001 vs. control group; ###, P<0.0001 vs. IL-1β treatment group, n=4-5).