Research Paper Volume 12, Issue 12 pp 12074—12085

Agonism of GPR120 prevented IL-1β-induced reduction of extracellular matrix through SOX-9

Figure 7. The effects of GW9508 on abolishing IL-1β-induced decreased SOX9 expression are dependent on GPR120. Cells were treated with IL-1β (10 ng/ml) with or without GW9508 (50 μM) or the GPR120 antagonist AH7614 (1 μM) for 24 h. (A) mRNA of SOX-9; (B) Protein of SOX-9 (^^^, P<0.0001 vs. control group; ***, P< 0.0001 vs. IL-1β treatment group, ###, P<0.0001 vs. IL-1β+ GW9508 group, n=4-5).