Research Paper Volume 12, Issue 12 pp 12142—12159

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Figure 2. The function of lysosome was impaired and the expression of axonal transport molecular motor was decreased in hippocampus of APP/PS1 double transgenic mice. (A) Transmission electron microscopy images of each group. (BE) Western blot analysis of (B, C) LC3II, and (D, E) P62 in each group. The data represent as mean {plus minus} SEM of a typical series of 3 experiments. (* P<0.05, versus Non Tg).