Research Paper Volume 12, Issue 12 pp 12142—12159

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Figure 3. NEW - The function of lysosome in hippocampus of APP/PS1 double transgenic mice was impaired and the expression of axonal transport molecular motor was decreased. (AD) Western blot analysis of LAMP2 (A, B) and CTSD (C, D) in each group. (EH) Western blot analysis of retrograde axonal transport molecular motor DIC (E, F) and forward axonal transport molecular motor KIF 5B (GH) in each group. The data represent as mean ± SEM of a typical series of 3 experiments. (# P<0.01, versus Non Tg; * P<0.01, versus Tg-3M).