Research Paper Volume 12, Issue 12 pp 12142—12159

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Figure 4. Decreased expression of retrograde axon transport related proteins P150, P50, Rab7 and ORP1L in hippocampus of APP/PS1 double transgenic mice with age. (A, B) Western blot analysis of dynactin proteins P150 and P50 in each group. (C, D) Western blot analysis of Rab7 and ORP1L in each group. The data represent as mean {plus minus} SEM of a typical series of 3 experiments. (# P<0.01, versus Non-Tg; * P<0.01, versus Tg-6M)