Research Paper Volume 12, Issue 12 pp 12142—12159

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Figure 7. DIC promoted the degradation of hippocampal autophagosomes and improved the function of lysosomes in APP/PS1 double transgenic mice. (AD) Western blot analysis of (A, B) LC3II, and (C, D) P62 in each group. (EH) Western blot analysis of (E, F) LAMP2, and (GH) CTSD in each group. The data represent as mean ± SEM of a typical series of 3 experiments. (# P>0.05,* P<0.01, versus Tg).