Research Paper Volume 12, Issue 12 pp 12142—12159

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Figure 8. DIC inhibited the expression of KIF5B and enhanced the expression of P150, P50 and Rab7 in hippocampus of APP/PS1 double transgenic mice. (AB) Western blot analysis of forward axonal transport molecular motor KIF5Bin each group. (CD) Western blot analysis of dynactin proteins P150 and P50 in each group. (EF) Western blot analysis of Rab7 in each group. The data represent as mean {plus minus} SEM of a typical series of 3 experiments. (# P>0.05,* P<0.01,versus Tg).