Research Paper Volume 12, Issue 12 pp 12142—12159

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Figure 9. The mechanism of DIC improves cognitive function by enhancing autophagic retrograde axonal transport-related proteins in AD. (A) Autophagy is activated in the hippocampus of APP/PS1 double transgenic mice. However, the function of lysosome and the process of autophagy axonal transport are impaired, which leads to the accumulation of insoluble Aβ and autophagosomes in the hippocampus. And with the increase of the age of mice, these injuries were gradually aggravated. (B) After overexpressing of DIC, the cognitive function of mice was improved and the aggregation of insoluble Aβ decreased. It may be achieved by improving the function of lysosomes and the expression of proteins related to autophagy axonal transport.