Research Paper Volume 12, Issue 12 pp 12206—12221

Prenatal famine exposure and estimated glomerular filtration rate across consecutive generations: association and epigenetic mediation in a population-based cohort study in Suihua China

Figure 1. Genome-wide DNA methylation changes in the participants prenatally exposed to famine. Circos plot depicting the entire autosomal complement. Each dot marks the location of the Illumina Methylation EPIC Bead probe along the genome. The dots on the innermost black ring and the next outermost black circle represent the CPG sites in the F1 generation and F2 generation, respectively. Green and red dots represent significantly hypo-methylated and hyper-methylated differentially methylated sites. The innermost black ring with vertical lines represents autosome ideograms annotated with the chromosomal number.