Review Volume 12, Issue 14 pp 15169—15182

Role of CPEB3 protein in learning and memory: new insights from synaptic plasticity


Figure 1. Structural features of CPEB3. (A) Primary features of CPEB3. The C terminal fragment of CPEB3 contains two highly conserved RNA recognition motifs (RRM1in forest green and RRM2 in blue) and one zinc-finger domain (Zif, in purple). A highly variable regulatory domain is embedded in the N terminal part of CPEB3. (B) Sequence alignment of human CPEB3 and CPEB4. Highly conserved residues between CPEB3 and CPEB4 are marked in red. The secondary structural element labeled on top of the corresponding residues are based on the reported fragment structure of CPEB4 (PDB number: 2MKJ). Numbering of amino acids corresponds to the CPEB4 protein. (C) Superposition of the reported CPEB3’s RRM1(PDB number:2RUG) and CPEB4’s RRM1 and RRM2 (PDB number: 2MKJ). The structure of CPEB3’s RRM1 and CPEB4’s RRM1 and RRM2 are displayed in cartoon and colored with forest green and pink, respectively.