Figure 4. Skin microbiota has a significant difference between the model group and GLSO group on day 5. (A) Principal Component Analysis (PCA) which used variance decomposition to reflect the differences between multiple groups of data on a two-dimensional coordinate chart showed differences in clustering of microbial communities. (B) Unweighted Pair-group Method with Arithmetic Mean (UPGMA) analysis combined with histogram of species distribution in genus level was used to present the microbial similarities of each group and relative abundance. (C) Histogram of species distribution was used to compare the differences of relative abundance in genus levels between different groups. Line Discriminant Analysis Effect Size (LEfSe) analysis showed significant dominant bacteria on each group (D) and the abundance of six of these bacteria in genus levels (E). All analysis above were based on unweighted UniFrac.