COVID-19 Research Paper Volume 12, Issue 11 pp 10087—10098

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

Figure 2. TMPRSS2 expression levels and eQTLs. (A) Both panels show TMPRSS2 mRNA expression levels in human normal lung samples stratified according to sex. On the left, data were retrieved for a total of 578 RNAseq experiments from the GTex repository. Expression levels are reported as transcripts per kilobase million (TPM). On the right, data were collected for a total of 170 microarray experiments from the GEO database. Expression levels are reported as normalized signal intensities. P values were calculated by using either the Kruskal-Wallis or the student t test. (B) Screenshot from the UCSC Genome browser (; GRCh37/hg19) highlighting the TMPRSS2 region (coordinates chr21: 42,835,000-42,905,000). The panel shows the following tracks: i) the ruler with the scale at the genomic level; ii) chromosome 21 nucleotide numbering; iii) the UCSC RefSeq track; iv) enhancers (grey and red bars) from GeneHancer database; v) interactions (curved lines) connecting GeneHancer regulatory elements and genes: all curved lines converge towards the androgen-responsive enhancer for the TMPRSS2 gene described by Clinckemalie and colleagues [29].