Research Paper Volume 12, Issue 12 pp 12285—12304

Influences of circulatory factors on intervertebral disc aging phenotype

Figure 7. Summary of the effects of circulatory factors on the disc aging phenotype. Young mice exposed to old blood exhibited a small, albeit insignificant increase in disc cellular senescence, but a significant increase in disc matrix PG imbalance and tissue degeneration. Old mice exposed to young blood showed a significant decrease in disc cellular senescence, but only a modest improvement in disc matrix PG homeostasis and tissue morphology. Black arrows=decreasing effects; red arrows=increasing effects; grey arrows=no effects. Magnitude of effect is indicated by size of arrow.