Figure 7. Summary of the effects of circulatory factors on the disc aging phenotype. Young mice exposed to old blood exhibited a small, albeit insignificant increase in disc cellular senescence, but a significant increase in disc matrix PG imbalance and tissue degeneration. Old mice exposed to young blood showed a significant decrease in disc cellular senescence, but only a modest improvement in disc matrix PG homeostasis and tissue morphology. Black arrows=decreasing effects; red arrows=increasing effects; grey arrows=no effects. Magnitude of effect is indicated by size of arrow.