Research Paper Volume 12, Issue 17 pp 16803—16819

Anchorage independence altered vasculogenic phenotype of melanoma cells through downregulation in aminopeptidase N /syndecan-1/integrin β4 axis

Figure 1. Loss of vasculogenic phenotype in the metastatic nodules formed by suspended melanoma cells. (A) Several white nodules were developed in the lungs of mice injected with either adherent or suspended melanoma cells. (B) HE staining and CD31 immunostaining showed vascular structures in the tumor nodules derived from adherent melanoma cells, but not seen in those from suspended melanoma cells.