Research Paper Volume 12, Issue 17 pp 16803—16819

Anchorage independence altered vasculogenic phenotype of melanoma cells through downregulation in aminopeptidase N /syndecan-1/integrin β4 axis

Figure 4. Integrin β4 expression was downregulated upon suppression of SDC1 expression. (A) Effect of SDC1 downregulation at expression of integrin isoforms as examined by qPCR. Data were mean ±S.D. (n=3); **, p < 0.01. (B) Integrin α6, β2, and β4 protein expression after SDC1 downregulation as examined by western blot. (C) SDC1 downregulation by shSDC1 did not change the level of ANPEP expression as examined by qPCR. Data were mean ±S.D. (n=3).