Research Paper Volume 12, Issue 14 pp 14189—14204

Co-exposure to multi-walled carbon nanotube and lead ions aggravates hepatotoxicity of nonalcoholic fatty liver via inhibiting AMPK/PPARγ pathway

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Figure 10.

Intervening AMPK/PPARγ pathway significantly changed the hepatotoxicity of MWCNTs + PbAc to NAFLD mice. (A) Upon the administration of MWCNTs + PbAc, NAFLD mice were simultaneously treated with vehicle, PF-06409577 and PF-06409577 + T0070907. Masson staining and Oil red O staining were performed to detect the hepatic fibrosis (blue indicates collagen) and steatosis (red indicates lipid) in NAFLD mice, respectively. (B) The expression levels of IL-6, IL-1β and TNF-α in NAFLD mice livers were measured (**P<0.01 and *P<0.05, compared to PF-06409577).