Research Paper Volume 12, Issue 14 pp 14189—14204

Co-exposure to multi-walled carbon nanotube and lead ions aggravates hepatotoxicity of nonalcoholic fatty liver via inhibiting AMPK/PPARγ pathway

Figure 3. Combined administration of MWCNTs and PbAc significantly damaged the liver function in NAFLD mice. The effects of low dose of PbAc, MWCNTs or MWCNTs + PbAc on the serum levels of CHOL, TG, HDL, LDL (A, B) and the TG expression levels in liver tissues (C, D) in the control and NAFLD mice. (E, F) Changes in the serum levels of ALT, AST and ALP in the control and NAFLD mice upon the low dose of PbAc, MWCNTs or MWCNTs + PbAc administration (*P<0.05 and **P<0.01, compared to PbAc or MWCNTs).