Research Paper Volume 12, Issue 14 pp 14232—14243

Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression


Figure 1. Mino inhibited microglial activation in the striatum and substantia nigra (SN) of mice injected with AAV hm-αSyn. (A) Mutant-αSyn-GFP expression after AAV SN injection in different groups. (B) Iba1 expression in different groups. (C) Quantification of mutant-αSyn-GFP expression after Mino treatment; there was no difference among the groups. (D) Mino inhibited Iba1 expression in the SN and striatum, as denoted by the number of Iba1+ cells in the SN. Data are expressed as the mean ± standard deviation (SD); **P < 0.01; *P < 0.05.