Research Paper Volume 12, Issue 14 pp 14232—14243

Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression


Figure 2. Mino administration after AAV injection prevented the loss of dopaminergic cell bodies in the substantia nigra (SN) and striatal fibers. (A) Immunohistochemical staining of the tyrosine hydroxylase (TH)+ cells in the striatum and SN. (B, C) Quantification of TH+ cells in SN and fibers in striatum. Data are expressed as the mean ± standard deviation (SD). *P < 0.05; **P < 0.01.