Research Paper Volume 12, Issue 14 pp 14232—14243

Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression


Figure 3. Mino enhanced the dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the nigrostriatal system after hmαSyn overexpression. Mino administration reversed the significant DA (A) and DOPAC (B) reduction caused by hmαSyn overexpression. Bars represent the mean ± standard deviation (SD). *P < 0.05, **P < 0.01.