Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression

Yong Wang; Qian Wang; Ruobing Yu; Qi Zhang; Zhonghai Zhang; Haiying Li; Chao Ren; Rongli Yang; Haichen Niu

doi:doi:10.18632/aging.103440

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Research Paper Volume 12, Issue 14 pp 14232—14243

Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression

Figure 6. Mino administration decreased the Lewy-body pathology in the substantia nigra (SN). (A) Mino decreased the pS129 αSyn signal induced by hmαSyn overexpression in the SN. (B) Quantitative analysis for the pS129 signals in the SN.