Research Paper Volume 12, Issue 14 pp 14285—14299

C5aR deficiency attenuates the breast cancer development via the p38/p21 axis

Figure 3. Reduced p-p21/p21 expression in tumoral tissues of patients with breast cancer. (A) Positive correlation of the disease-free survival rate of patients with the levels of p-p21 expression. (B, C) P-p21 expression in BC tumoral tissues (T) and BC-adjacent non-tumoral tissues (N) of patients with different clinical stages was evaluated by immunohistochemistry and western blotting. *P < 0.05, **P < 0.01, Equal protein loading in all lanes was confirmed by probing the blots with anti- GAPDH antibody. Magnification: 200×. The experiments were repeated in triplicate.