Research Paper Volume 12, Issue 14 pp 14300—14313

Caveolin-3 protects diabetic hearts from acute myocardial infarction/reperfusion injury through β2AR, cAMP/PKA, and BDNF/TrkB signaling pathways

Figure 1. Myocardial ischemia reperfusion (I/R) injury model in diabetes mellitus (DM) rats SD rats were subjected to DM induction and then received coronary artery ligation to induce myocardial infarction (MI). Rats were randomly assigned to three groups: sham surgery group, DM group, I/R group, and I/R + DM group. (A) Representative photos of myocardial infarct size. Four weeks after I/R operation, rats were then examined for (A, C, D, E, and F) LVIDs, LVIDd, LVEF, and LVFS by echocardiography; (B) myocardial infarct size. N=5. **P<0.01, compared to sham group; #P<0.05, ##P<0.01, compared to DM group; && P<0.01, compared to I/R group.