Research Paper Volume 12, Issue 14 pp 14314—14328

Circular RNA-9119 suppresses in ovarian cancer cell viability via targeting the microRNA-21-5p–PTEN–Akt pathway

Figure 8. Xenograft pancreatic cancer formation is suppressed by circ9119 in mice. SKOV-3 cells transfected with lentiviral-circ9119 or NC cells were administered to the mice subcutaneously (n = 8 in each group). At day 30 post inoculation, we euthanized the animals and weighed the tumors. (A) circ9119, (B) miR-21, and (C) PTEN mRNA expression in OC cells was measured in each group using qRT–PCR. (D) three representative images of tumors in each group were displayed. (E) Tumor development curve at 27 days post inoculation. (F) Tumors from each group were weighed following excision. *P < 0.05 vs. the NC group.