Research Paper Volume 12, Issue 14 pp 14329—14340

Downregulation of hsa_circ_0007580 inhibits non-small cell lung cancer tumorigenesis by reducing miR-545-3p sponging

Figure 1. Differentially expressed circRNAs in NSCLC. The differentially expressed circRNAs between NSCLC tissues and adjacent normal tissues in (A) GSE101586 or (B) GSE112214 were assessed using principal component analysis and a volcano plot. Red indicates high expression while blue indicates low expression. (C) Among the differentially expressed circRNAs in GSE101586, 18 were downregulated and 107 were upregulated in NSCLC tissues. In GSE112214, 423 circRNAs were downregulated and 319 were upregulated in NSCLC tissues. (D) The overlapping differentially expressed circRNAs between GSE101586 and GSE112214 were analyzed.