Research Paper Volume 12, Issue 14 pp 14341—14354

LKB1 inactivation leads to centromere defects and genome instability via p53-dependent upregulation of survivin

Figure 6. Survivin mediates chromosomal and genomic instability induced by LKB1 deficiency. (A) Western blotting detection of survivin expression after transfection of sh-survivin into U2OS/sh-LKB1 cells. (B) DAPI staining showing multinucleated cells after sh-survivin transfection.