Research Paper Volume 12, Issue 14 pp 14376—14390

MicroRNA-15a/16/SOX5 axis promotes migration, invasion and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes

Figure 2. Reciprocal repression between SOX5 and miR-15a/16. (A, B) RA-FLSs cell line of MH7A was transfected with miR-15a/16 mimics for 48h. SOX5 expression level was determined by RT-qPCR (A) and western-blot (B). (C) Graphs show the quantitation data derived from left western-blot figure. (D, E) MH7A was transfected with Ad-SOX5 for 48h. The expressions of miR-15a (D) and miR-16 (E) were detected by RT-qPCR. Bars show the mean ± SD of 3 independent experiments.