Figure 5. Regulation of miR-15a/16/SOX5 axis on cytokine production in RA-FLSs. (A, B) Following transfected with miR-15a, miR-16 mimics and miR-control for 48h, expression of IL-1β,TNF-α, IL-6, IL-17 (A), MMP-1, MMP-3 and MMP-9 (B) was detected by RT-qPCR. (C, D) SOX5 overexpression alleviates the miR-15a/16 mimics-mediated inhibitory roles on IL-1β (C) and TNF-α (D) expression in FLSs. Bars show the mean ± SD of 3 independent experiments.