Research Paper Volume 12, Issue 14 pp 14406—14417

Osthole resensitizes CD133+ hepatocellular carcinoma cells to cisplatin treatment via PTEN/AKT pathway

Figure 2. Effect of PTEN on regulating the cisplatin sensitivity of CD133+ and CD133- HCC cells. (A) expression of PTEN in CD133+ and CD133- Huh7 and HepG2 cells. &P<0.05 vs. CD133- Huh7 cells, #P<0.05 vs. CD133- HepG2 cells. (B) Transfection with PTEN plasmid increased the expression of PTEN in CD133+ Huh7 and HepG2 cells. *P<0.05. (C) Transfection with PTEN plasmid increased the sensitivity of CD133+ Huh7 and HepG2 cells to cisplatin (5 μM) treatment. *P<0.05. (D) Transfection with PTEN siRNA decreased the expression of PTEN in CD133- Huh7 and HepG2 cells. *P<0.05. (E) Transfection with PTEN siRNA decreased the sensitivity of CD133- Huh7 and HepG2 cells to cisplatin (5 μM) treatment. *P<0.05.