Figure 2. Relationships of plasma SHBG with hippocampus atrophy, brain metabolism decline, and cognitive decline. Individuals with higher SHBG showed faster rate of hippocampus atrophy (A) and brain metabolism decline (B). Individuals with higher plasma SHBG levels exhibited faster decline in general cognition (C and D), memory function (E), and executive function (F). All models were adjusted for age, sex, education, APOE4 status, and baseline diagnosis. Abbreviations: ADAS = Alzheimer’s Disease Assessment Scale; MEM = Memory function; EF = Executive function. The first p value with index ® indicates the relationships between baseline plasma SHBG and change rates of the above phenotypes over follow-up. The second p value represents association results from the linear mixed effects models.